EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytes

EGF signaling promotes the lineage conversion of astrocytes into oligodendrocytes

Abstract Background The conversion of astrocytes activated by nerve injuries to oligodendrocytes is not only beneficial to axonal remyelination, but also helpful for reversal of glial scar. Recent studies have shown that pathological niche promoted the Sox10-mediated astrocytic transdifferentiation...

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Bibliographic Details
Main Authors: Xinyu Liu, Conghui Li, Jiao Li, Lesi Xie, Zeng Hong, Kang Zheng, Xiaofeng Zhao, Aifen Yang, Xiaofeng Xu, Huaping Tao, Mengsheng Qiu, Junlin Yang
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Molecular Medicine
Subjects:
Astrocyte
Oligodendrocyte
Transdifferentiation
EGF
Erk1/2
Online Access:https://doi.org/10.1186/s10020-022-00478-5

Internet

https://doi.org/10.1186/s10020-022-00478-5

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