Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach

Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach

Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical...

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Bibliographic Details
Main Authors: Jelena R. Mitrović, Branka Divović-Matović, Daniel E. Knutson, Jelena B. Đoković, Aleksandar Kremenović, Vladimir D. Dobričić, Danijela V. Randjelović, Ivana Pantelić, James M. Cook, Miroslav M. Savić, Snežana D. Savić
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
pyrazoloquinolinones
nanocrystals
wet media milling
fasted/fed bioavailability
Online Access:https://www.mdpi.com/1999-4923/13/8/1188

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https://www.mdpi.com/1999-4923/13/8/1188

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