The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization

The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization

BackgroundInflammatory bowel disease (IBD) is a chronic immune-mediated disorder affecting millions worldwide. Due to the complexity of its pathogenesis, the treatment options for IBD are limited. This study focuses on ELF4, a member of the ETS transcription factor family, as a target to elucidate i...

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Bibliographic Details
Main Authors: Meiwan Cao, Peiyu Chen, Baoling Peng, Yang Cheng, Jing Xie, Ziang Hou, Huan Chen, Liping Ye, Huiwen Li, Hongli Wang, Lu Ren, Liya Xiong, Lanlan Geng, Sitang Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
transcription regulator ELF4
inflammatory bowel disease
IL1RN
Th17 cells
macrophage M2 polarization
inflammatory factors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270411/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270411/full

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