Characterization of brain resilience in Alzheimer's disease using polygenic risk scores and further improvement by integrating mitochondria-associated loci

Introduction: Identification of high-risk people for Alzheimer's disease (AD) is critical for prognosis and early management. Longitudinal epidemiologic studies have observed heterogeneity in the brain and cognitive aging. Brain resilience was described as above-expected cognitive function. The...

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Bibliographic Details
Main Authors: Xuan Xu, Hui Wang, David A. Bennett, Qing-Ye Zhang, Xiang-Yu Meng, Hong-Yu Zhang
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Journal of Advanced Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123223000711