Changes in Plasma Itaconate Elevation in Early Rheumatoid Arthritis Patients Elucidates Disease Activity Associated Macrophage Activation

Changes in Plasma Itaconate Elevation in Early Rheumatoid Arthritis Patients Elucidates Disease Activity Associated Macrophage Activation

Changes in the plasma metabolic profile were characterised in newly diagnosed rheumatoid arthritis (RA) patients upon commencement of conventional disease-modifying anti-rheumatic drug (cDMARD) therapy. Plasma samples collected in an early RA randomised strategy study (NCT00920478) that compared cli...

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Bibliographic Details
Main Authors: Rónán Daly, Gavin Blackburn, Cameron Best, Carl S. Goodyear, Manikhandan Mudaliar, Karl Burgess, Anne Stirling, Duncan Porter, Iain B. McInnes, Michael P. Barrett, James Dale
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Metabolites
Subjects:
rheumatoid arthritis
DMARD
macrophage
itaconate
inflammation
liquid chromatography–mass spectrometry (LC-MS)
Online Access:https://www.mdpi.com/2218-1989/10/6/241

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https://www.mdpi.com/2218-1989/10/6/241

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