Clustering by plasma lipoprotein profile reveals two distinct subgroups with positive lipid response to fenofibrate therapy.

Clustering by plasma lipoprotein profile reveals two distinct subgroups with positive lipid response to fenofibrate therapy.

Fibrates lower triglycerides and raise HDL cholesterol in dyslipidemic patients, but show heterogeneous treatment response. We used k-means clustering to identify three representative NMR lipoprotein profiles for 775 subjects from the GOLDN population, and study the response to fenofibrate in corres...

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Bibliographic Details
Main Authors: Kees van Bochove, Daniël B van Schalkwijk, Laurence D Parnell, Chao-Qiang Lai, José M Ordovás, Albert A de Graaf, Ben van Ommen, Donna K Arnett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3373573?pdf=render

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http://europepmc.org/articles/PMC3373573?pdf=render

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