Novel Indole-Tethered Chromene Derivatives: Synthesis, Cytotoxic Properties, and Key Computational Insights

Novel Indole-Tethered Chromene Derivatives: Synthesis, Cytotoxic Properties, and Key Computational Insights

Indole-tethered chromene derivatives were synthesised in a one-pot multicomponent reaction using <i>N</i>-alkyl-1<i>H</i>-indole-3-carbaldehydes, 5,5-dimethylcyclohexane-1,3-dione, and malononitrile, catalysed by DBU at 60–65 °C in a short reaction time. The benefits of the m...

Full description

Bibliographic Details
Main Authors: M. Shaheer Malik, Hissana Ather, Shaik Mohammad Asif Ansari, Ayesha Siddiqua, Qazi Mohammad Sajid Jamal, Ali H. Alharbi, Munirah M. Al-Rooqi, Rabab S. Jassas, Essam M. Hussein, Ziad Moussa, Rami J. Obaid, Saleh A. Ahmed
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
chromenes
indole
multicomponent reaction
anti-cancer activity
molecular docking
ADME
Online Access:https://www.mdpi.com/1424-8247/16/3/333

Internet

https://www.mdpi.com/1424-8247/16/3/333

Similar Items