Comprehensive Comparison of the Capacity of Functionalized Sepharose, Magnetic Core, and Polystyrene Nanoparticles to Immuno-Precipitate Procalcitonin from Human Material for the Subsequent Quantification by LC-MS/MS

Comprehensive Comparison of the Capacity of Functionalized Sepharose, Magnetic Core, and Polystyrene Nanoparticles to Immuno-Precipitate Procalcitonin from Human Material for the Subsequent Quantification by LC-MS/MS

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The fast and accurate diagnosis of sepsis by procalcitonin (PCT) has emerged as an essential tool in clinical medicine. Although in use in the clinical laboratory for a long time, PCT quantification h...

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Bibliographic Details
Main Authors: Thomas Masetto, Kai Matzenbach, Thomas Reuschel, Sebastian-Alexander Tölke, Klaus Schneider, Lea Marie Esser, Marco Reinhart, Laura Bindila, Christoph Peter, Matthias Grimmler
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
sepsis
procalcitonin
LC-MS/MS quantification
standardization
immuno-enrichment
biopolymers
Online Access:https://www.mdpi.com/1422-0067/24/13/10963

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https://www.mdpi.com/1422-0067/24/13/10963

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