Uncovering the significance of expanded CD8+ large granular lymphocytes in inclusion body myositis: Insights into T cell phenotype and functional alterations, and disease severity

Uncovering the significance of expanded CD8+ large granular lymphocytes in inclusion body myositis: Insights into T cell phenotype and functional alterations, and disease severity

IntroductionInclusion body myositis (IBM) is a progressive inflammatory myopathy characterised by skeletal muscle infiltration and myofibre invasion by CD8+ T lymphocytes. In some cases, IBM has been reported to be associated with a systemic lymphoproliferative disorder of CD8+ T cells exhibiting a...

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Bibliographic Details
Main Authors: Emily McLeish, Anuradha Sooda, Nataliya Slater, Barbara Kachigunda, Kelly Beer, Shereen Paramalingam, Phillipa J. Lamont, Abha Chopra, Frank Louis Mastaglia, Merrilee Needham, Jerome David Coudert
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
inclusion body myositis
T cell large granular lymphocytes
inhibitory natural killer receptors
KLRG1
senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1153789/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1153789/full

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