PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina

PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina

The in vivo neuroprotective effect of PhTx3-4, a spider toxin N-P/Q calcium channel blocker, was studied in a rat model of NMDA-induced injury of the retina. NMDA (N-Methyl-d-Aspartate)-induced retinal injury in rats reduced the b-wave amplitude by 62% ± 3.6%, indicating the severity of the insult....

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Bibliographic Details
Main Authors: Nancy Scardua Binda, Charles Porto Petruceli Carayon, Rafael Mourão Agostini, Ana Cristina do Nascimento Pinheiro, Marta Nascimento Cordeiro, Marco Aurélio Romano Silva, Juliana Figueira Silva, Elizete Maria Rita Pereira, Claudio Antonio da Silva Junior, Célio José de Castro Junior, Andre Luiz Sena Guimarães, Marcus Vinicius Gomez
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:Toxins
Subjects:
Neuroprotection
retina
phoneutria nigriventer
spider toxins
PhTx3-4
Online Access:http://www.mdpi.com/2072-6651/8/3/70

Internet

http://www.mdpi.com/2072-6651/8/3/70

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