Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: A longitudinal in-vivo study

Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: A longitudinal in-vivo study

Carbon-11 labeled dihydrotetrabenazine (11C-DTBZ) binds to the vesicular monoamine transporter 2 and has been used to assess nigro-striatal integrity in animal models and patients with Parkinson's disease. Here, we applied 11C-DTBZ positron emission tomography (PET) to obtain longitudinally in-...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Francisco Molinet-Dronda, Belén Gago, Ana Quiroga-Varela, Carlos Juri, María Collantes, Mercedes Delgado, Elena Prieto, Margarita Ecay, Elena Iglesias, Concepció Marín, Iván Peñuelas, José A. Obeso
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: Elsevier 2015-05-01
Цуврал:Neurobiology of Disease
Нөхцлүүд:
Parkinson's disease
6-Hydroxydopamine
Positron emission tomography
[11C]-dihydrotetrabenazine (11C-DTBZ)
Nigro-striatal depletion
Dopaminergic marker
Онлайн хандалт:http://www.sciencedirect.com/science/article/pii/S0969996115000194

Интернэт

http://www.sciencedirect.com/science/article/pii/S0969996115000194

Ижил төстэй зүйлс