Improved production of germacrene A, a direct precursor of ß-elemene, in engineered Saccharomyces cerevisiae by expressing a cyanobacterial germacrene A synthase

Improved production of germacrene A, a direct precursor of ß-elemene, in engineered Saccharomyces cerevisiae by expressing a cyanobacterial germacrene A synthase

Abstract Background The sesquiterpene germacrene A is a direct precursor of ß-elemene that is a major component of the Chinese medicinal herb Curcuma wenyujin with prominent antitumor activity. The microbial platform for germacrene A production was previously established in Saccharomyces cerevisiae...

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Bibliographic Details
Main Authors: Weixin Zhang, Junqi Guo, Zheng Wang, Yanwei Li, Xiangfeng Meng, Yu Shen, Weifeng Liu
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Microbial Cell Factories
Subjects:
ß-elemene
Germacrene A
Germacrene A synthase
Site-directed mutagenesis
Metabolic engineering
Online Access:https://doi.org/10.1186/s12934-020-01500-3

Internet

https://doi.org/10.1186/s12934-020-01500-3

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