Strong, Long-Term Transgene Expression in Rat Liver Using Chicken β-Actin Promoter Associated with Cytomegalovirus Immediate-Early Enhancer (CAG Promoter)

Strong, Long-Term Transgene Expression in Rat Liver Using Chicken β-Actin Promoter Associated with Cytomegalovirus Immediate-Early Enhancer (CAG Promoter)

For successful gene therapy in hepatic enzyme deficiencies, it is essential to use promoters that can maintain strong transcriptional activity for the long term in the liver. Using Gunn rats, a model animal for Crigler-Najjar syndrome type I, the long-term transcriptional function of the CAG promote...

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Bibliographic Details
Main Authors: Motomichi Kosuga, Shin Enosawa, Xiao-Kang Li, Seiichi Suzuki, Nobutake Matsuo, Masao Yamada, Jayanta Roy-Chowdhury, Osamu Koiwai, Torayuki Okuyama
Format: Article
Language:English
Published: SAGE Publishing 2000-09-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/096368970000900513

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https://doi.org/10.1177/096368970000900513

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