Evolution of naturally arising SARS-CoV-2 defective interfering particles

Evolution of naturally arising SARS-CoV-2 defective interfering particles

Genomes from defective interfering (DI) particles following serial passaging of SARS-CoV-2 reveal a fusion protein that attenuates viral replication. Synthetic, recombinant DI genomes are designed to interfere with SARS-CoV-2 replication.

Bibliographic Details
Main Authors: Samer Girgis, Zaikun Xu, Spyros Oikonomopoulos, Alla D. Fedorova, Egor P. Tchesnokov, Calvin J. Gordon, T. Martin Schmeing, Matthias Götte, Nahum Sonenberg, Pavel V. Baranov, Jiannis Ragoussis, Tom C. Hobman, Jerry Pelletier
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04058-5

Internet

https://doi.org/10.1038/s42003-022-04058-5

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