Evolution of naturally arising SARS-CoV-2 defective interfering particles
Genomes from defective interfering (DI) particles following serial passaging of SARS-CoV-2 reveal a fusion protein that attenuates viral replication. Synthetic, recombinant DI genomes are designed to interfere with SARS-CoV-2 replication.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04058-5 |
| _version_ | 1811335183471738880 |
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| author | Samer Girgis Zaikun Xu Spyros Oikonomopoulos Alla D. Fedorova Egor P. Tchesnokov Calvin J. Gordon T. Martin Schmeing Matthias Götte Nahum Sonenberg Pavel V. Baranov Jiannis Ragoussis Tom C. Hobman Jerry Pelletier |
| author_facet | Samer Girgis Zaikun Xu Spyros Oikonomopoulos Alla D. Fedorova Egor P. Tchesnokov Calvin J. Gordon T. Martin Schmeing Matthias Götte Nahum Sonenberg Pavel V. Baranov Jiannis Ragoussis Tom C. Hobman Jerry Pelletier |
| author_sort | Samer Girgis |
| collection | DOAJ |
| description | Genomes from defective interfering (DI) particles following serial passaging of SARS-CoV-2 reveal a fusion protein that attenuates viral replication. Synthetic, recombinant DI genomes are designed to interfere with SARS-CoV-2 replication. |
| first_indexed | 2024-04-13T17:20:23Z |
| format | Article |
| id | doaj.art-5e493b54c37c47c3a8ea41d5c87f53e3 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T17:20:23Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-5e493b54c37c47c3a8ea41d5c87f53e32022-12-22T02:38:00ZengNature PortfolioCommunications Biology2399-36422022-10-015111210.1038/s42003-022-04058-5Evolution of naturally arising SARS-CoV-2 defective interfering particlesSamer Girgis0Zaikun Xu1Spyros Oikonomopoulos2Alla D. Fedorova3Egor P. Tchesnokov4Calvin J. Gordon5T. Martin Schmeing6Matthias Götte7Nahum Sonenberg8Pavel V. Baranov9Jiannis Ragoussis10Tom C. Hobman11Jerry Pelletier12Department of Biochemistry, McGill UniversityDepartment of Cell Biology, U AlbertaMcGill Genome Centre, Department of Human Genetics, McGill UniversitySchool of Biochemistry and Cell Biology, University College CorkDepartment of Medical Microbiology and Immunology, University of AlbertaDepartment of Medical Microbiology and Immunology, University of AlbertaDepartment of Biochemistry, McGill UniversityDepartment of Medical Microbiology and Immunology, University of AlbertaDepartment of Biochemistry, McGill UniversitySchool of Biochemistry and Cell Biology, University College CorkMcGill Genome Centre, Department of Human Genetics, McGill UniversityDepartment of Cell Biology, U AlbertaDepartment of Biochemistry, McGill UniversityGenomes from defective interfering (DI) particles following serial passaging of SARS-CoV-2 reveal a fusion protein that attenuates viral replication. Synthetic, recombinant DI genomes are designed to interfere with SARS-CoV-2 replication.https://doi.org/10.1038/s42003-022-04058-5 |
| spellingShingle | Samer Girgis Zaikun Xu Spyros Oikonomopoulos Alla D. Fedorova Egor P. Tchesnokov Calvin J. Gordon T. Martin Schmeing Matthias Götte Nahum Sonenberg Pavel V. Baranov Jiannis Ragoussis Tom C. Hobman Jerry Pelletier Evolution of naturally arising SARS-CoV-2 defective interfering particles Communications Biology |
| title | Evolution of naturally arising SARS-CoV-2 defective interfering particles |
| title_full | Evolution of naturally arising SARS-CoV-2 defective interfering particles |
| title_fullStr | Evolution of naturally arising SARS-CoV-2 defective interfering particles |
| title_full_unstemmed | Evolution of naturally arising SARS-CoV-2 defective interfering particles |
| title_short | Evolution of naturally arising SARS-CoV-2 defective interfering particles |
| title_sort | evolution of naturally arising sars cov 2 defective interfering particles |
| url | https://doi.org/10.1038/s42003-022-04058-5 |
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