The molecular heterogeneity of the precancerous breast affects drug efficacy

Abstract In the therapeutic domain, targeted therapies have been shown to be generally more effective when given to patients with tumors that harbor the targeted aberration. This principle has not been tested in cancer prevention despite evidence that molecular heterogeneity accompanies the multi-st...

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Bibliographic Details
Main Authors: Anjana Bhardwaj, Raniv Dawey Rojo, Zhenlin Ju, Alexander Koh, Kazunoshin Tachibana, Jing Wang, Isabelle Bedrosian
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-16779-y