LC-MS Quantification of Site-Specific Phosphorylation Degree by Stable-Isotope Dimethyl Labeling Coupled with Phosphatase Dephosphorylation

LC-MS Quantification of Site-Specific Phosphorylation Degree by Stable-Isotope Dimethyl Labeling Coupled with Phosphatase Dephosphorylation

Protein phosphorylation is a crucial post-translational modification that plays an important role in the regulation of cellular signaling processes. Site-specific quantitation of phosphorylation levels can help decipher the physiological functions of phosphorylation modifications under diverse physi...

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Bibliographic Details
Main Authors: Sin-Hong Chen, Ya-Chi Lin, Ming-Kuei Shih, Li-Fei Wang, Shyh-Shyan Liu, Jue-Liang Hsu
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
phosphorylation degree
stable-isotope dimethyl labeling
phosphatase dephosphorylation
LC-MS
SRM
Online Access:https://www.mdpi.com/1420-3049/25/22/5316

Internet

https://www.mdpi.com/1420-3049/25/22/5316

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