Further Probing of Cu<sup>2+</sup>-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes

Further Probing of Cu<sup>2+</sup>-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes

Peptide nucleic acid (PNA)-neocuproine conjugates have been shown to efficiently catalyse the cleavage of RNA target sequences in the presence of Cu<sup>2+</sup> ions in a site-specific manner. These artificial enzymes are designed to force the formation of a bulge in the RNA target, the...

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Bibliographic Details
Main Authors: Olivia Luige, Merita Murtola, Alice Ghidini, Roger Strömberg
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
artificial ribonuclease
peptide nucleic acid
RNA cleavage
catalysis
Online Access:https://www.mdpi.com/1420-3049/24/4/672

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