First-in-human study of a novel cell death tracer [99mTc]Tc-Duramycin: safety, biodistribution and radiation dosimetry in healthy volunteers

First-in-human study of a novel cell death tracer [99mTc]Tc-Duramycin: safety, biodistribution and radiation dosimetry in healthy volunteers

Abstract Background Imaging of cell death can provide an early indication of treatment response in cancer. [99mTc]Tc-Duramycin is a small-peptide SPECT tracer that recognizes both apoptotic and necrotic cells by binding to phosphatidylethanolamine present in the cell membrane. Preclinically, this tr...

Full description

Bibliographic Details
Main Authors: Taco Metelerkamp Cappenberg, Stijn De Schepper, Christel Vangestel, Stef De Lombaerde, Leonie wyffels, Tim Van den Wyngaert, Jeffrey Mattis, Brian Gray, Koon Pak, Sigrid Stroobants, Filipe Elvas
Format: Article
Language:English
Published: SpringerOpen 2023-08-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Cell death imaging
Apoptosis
99mTc-duramycin SPECT
Biodistribution
Internal dosimetry
Online Access:https://doi.org/10.1186/s41181-023-00207-1

Internet

https://doi.org/10.1186/s41181-023-00207-1

Similar Items