Pleiotropic Long-Term Effects of Atorvastatin on Posttraumatic Joint Contracture in a Rat Model

Pleiotropic Long-Term Effects of Atorvastatin on Posttraumatic Joint Contracture in a Rat Model

The antifibrotic effect of atorvastatin has already been demonstrated in several organ systems. In the present study, a rat model was used to investigate the effect of atorvastatin on posttraumatic joint contracture. Forty-eight Sprague Dawley rats were equally randomized into an atorvastatin group...

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Bibliographic Details
Main Authors: Erik Wegner, Ekaterina Slotina, Tim Mickan, Sebastian Truffel, Charlotte Arand, Daniel Wagner, Ulrike Ritz, Pol M. Rommens, Erol Gercek, Philipp Drees, Andreas Baranowski
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceutics
Subjects:
joint contracture
myofibroblast
atorvastatin
posttraumatic joint stiffness (PTJS)
antifibrotic drugs
rat model
Online Access:https://www.mdpi.com/1999-4923/14/3/523

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https://www.mdpi.com/1999-4923/14/3/523

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