The AMPK activator metformin improves recovery from demyelination by shifting oligodendrocyte bioenergetics and accelerating OPC differentiation

The AMPK activator metformin improves recovery from demyelination by shifting oligodendrocyte bioenergetics and accelerating OPC differentiation

Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to neurological dysfunction and, if myelin repair fails, neurodegeneration of the denuded axons. Virtually all treatments for M...

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Bibliographic Details
Main Authors: Mohanlall Narine, Maryam A. Azmi, Martin Umali, Ashley Volz, Holly Colognato
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
metformin
oligodendrocyte
metabolism
cuprizone
multiple sclerosis
myelin repair
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1254303/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1254303/full

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