Prostaglandin E1 Alleviates Cognitive Dysfunction in Chronic Cerebral Hypoperfusion Rats by Improving Hemodynamics

Prostaglandin E1 Alleviates Cognitive Dysfunction in Chronic Cerebral Hypoperfusion Rats by Improving Hemodynamics

Compensatory vascular mechanisms can restore cerebral blood flow (CBF) but fail to protect against chronic cerebral hypoperfusion (CCH)-mediated neuronal damage and cognitive impairment. Prostaglandin E1 (PGE1) is known as a vasodilator to protect against ischemic injury in animal models, but its pr...

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Bibliographic Details
Main Authors: Xiaomei Xie, Weibiao Lu, Yuanfang Chen, Chi Kwan Tsang, Jianye Liang, Wenxian Li, Zhen Jing, Yu Liao, Li’an Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Neuroscience
Subjects:
cerebral blood flow
chronic cerebral hypoperfusion
cognitive functions
neuronal damage
prostaglandin E1
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00549/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00549/full

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