Assembling structurally customizable synthetic carriers of siRNA through thermodynamically self-regulated process

Assembling structurally customizable synthetic carriers of siRNA through thermodynamically self-regulated process

This study demonstrates that our previously reported polywraplex, a synthetic siRNA carrier consisting of a uni-molecular polyplex core of customizable size and a self-assembled tri-block copolymer envelop, may be constructed using dendrimers as the crosslinking junctions. Replacing the branched low...

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Bibliographic Details
Main Authors: Guang Bai, Tong Xue, Xiaotao Dong, Uday Kumar Chinta, Jia Feng, Tuo Jin, Fei Wu
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Networked cationic polymer
Thermodynamically self-regulated processes
siRNA delivery
Unimolecular polyplex
Zeta potential regulated polymerization
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087618311577

Internet

http://www.sciencedirect.com/science/article/pii/S1818087618311577

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