Inosine reverses multidrug resistance in Gram-negative bacteria carrying mobilized RND-type efflux pump gene cluster tmexCD-toprJ

Inosine reverses multidrug resistance in Gram-negative bacteria carrying mobilized RND-type efflux pump gene cluster tmexCD-toprJ

ABSTRACT Antimicrobial resistance is rapidly increasing worldwide, highlighting the urgent need for pharmaceutical and nonpharmaceutical interventions to tackle different-to-treat bacterial infections. Tigecycline, a semi-synthesis glycylcycline for parenteral administration, is widely recognized as...

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Bibliographic Details
Main Authors: Fulei Li, Tianqi Xu, Dan Fang, Zhiqiang Wang, Yuan Liu
Format: Article
Language:English
Published: American Society for Microbiology 2024-10-01
Series:mSystems
Subjects:
antibiotic
antimicrobial resistance
inosine
metabolism
bacteria
Online Access:https://journals.asm.org/doi/10.1128/msystems.00797-24

Internet

https://journals.asm.org/doi/10.1128/msystems.00797-24

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