Serotonin 5-HT<sub>6</sub> Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity—Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer’s Disease

Serotonin 5-HT<sub>6</sub> Receptor Ligands and Butyrylcholinesterase Inhibitors Displaying Antioxidant Activity—Design, Synthesis and Biological Evaluation of Multifunctional Agents against Alzheimer’s Disease

Neurodegeneration leading to Alzheimer’s disease results from a complex interplay of a variety of processes including misfolding and aggregation of amyloid beta and tau proteins, neuroinflammation or oxidative stress. Therefore, to address more than one of these, drug discovery programmes focus on t...

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Bibliographic Details
Main Authors: Krzysztof Więckowski, Natalia Szałaj, Beata Gryzło, Tomasz Wichur, Izabella Góral, Emilia Sługocka, Joanna Sniecikowska, Gniewomir Latacz, Agata Siwek, Justyna Godyń, Adam Bucki, Marcin Kołaczkowski, Anna Więckowska
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
cholinesterase inhibitors
AChE
BuChE
5-HT<sub>6</sub> receptor ligands
antioxidant properties
Online Access:https://www.mdpi.com/1422-0067/23/16/9443

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https://www.mdpi.com/1422-0067/23/16/9443

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