Pycard and BC017158 Candidate Genes of Irm1 Locus Modulate Inflammasome Activation for IL-1β Production

Pycard and BC017158 Candidate Genes of Irm1 Locus Modulate Inflammasome Activation for IL-1β Production

We identified Pycard and BC017158 genes as putative effectors of the Quantitative Trait locus (QTL) that we mapped at distal chromosome 7 named Irm1 for Inflammatory response modulator 1, controlling acute inflammatory response (AIR) and the production of IL-1β, dependent on the activation of the NL...

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Main Authors: Andrea Borrego, Francesca Colombo, Jean Gabriel de Souza, José Ricardo Jensen, Alice Dassano, Rocco Piazza, Barbara Anaís Rodrigues dos Santos, Orlando Garcia Ribeiro, Marcelo De Franco, Wafa Hanna Koury Cabrera, Marcelo Yudi Icimoto, Nancy Starobinas, Geraldo Magalhães, Leticia Figueiredo Monteleone, Silas Fernandes Eto, Carlos DeOcesano-Pereira, Mauricio Barbugiani Goldfeder, Kerly Fernanda Mesquita Pasqualoto, Tommaso A. Dragani, Olga Célia Martinez Ibañez
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
Inflammation
genome screening
cancer
ASC specks
Interleukin-1
Interleukin-6
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.899569/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.899569/full

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