Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

The unfolded protein response (UPR) is an essential cell signaling system that detects the accumulation of misfolded proteins within the endoplasmic reticulum (ER) and initiates a cellular response in order to maintain homeostasis. How cells detect the accumulation of misfolded proteins remains uncl...

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Bibliographic Details
Main Authors: Marta Carrara, Filippo Prischi, Piotr R Nowak, Megan C Kopp, Maruf MU Ali
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-02-01
Series:eLife
Subjects:
UPR
ER stress
Ire1
perk
unfolded protein
Online Access:https://elifesciences.org/articles/03522

Internet

https://elifesciences.org/articles/03522

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