Novel genetic variant associated with globoid cell leukodystrophy in a family of mixed breed dogs

Novel genetic variant associated with globoid cell leukodystrophy in a family of mixed breed dogs

Abstract Background Globoid cell leukodystrophy (GCL) is a fatal autosomal recessive disease caused by variants in the galactosylceramidase (GALC) gene. Two dog breed‐specific variants are reported. Objectives Characterize the putatively causative GALC variant for GCL in a family of dogs and determi...

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Bibliographic Details
Main Authors: Samantha Hammack, Devon Wallis Hague, Miranda D. Vieson, Elizabeth Esdaile, Shayne S. Hughes, Rebecca R. Bellone, Annette M. McCoy
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Journal of Veterinary Internal Medicine
Subjects:
canine
congenital disease
GALC
Krabbe disease
neurologic disease
Online Access:https://doi.org/10.1111/jvim.16822

Internet

https://doi.org/10.1111/jvim.16822

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