Engineering ROS‐Responsive Bioscaffolds for Disrupting Myeloid Cell‐Driven Immunosuppressive Niche to Enhance PD‐L1 Blockade‐Based Postablative Immunotherapy

Engineering ROS‐Responsive Bioscaffolds for Disrupting Myeloid Cell‐Driven Immunosuppressive Niche to Enhance PD‐L1 Blockade‐Based Postablative Immunotherapy

Abstract The existence of inadequate ablation remains an important cause of treatment failure for loco‐regional ablation therapies. Here, using a preclinical model, it is reported that inadequate microwave ablation (iMWA) induces immunosuppressive niche predominated by myeloid cells. The gene signat...

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Bibliographic Details
Main Authors: Shaoyue Li, Chunyan Zhu, Xianli Zhou, Liang Chen, Xiaowan Bo, Yuting Shen, Xin Guan, Xiaoxia Han, Dandan Shan, Liping Sun, Yu Chen, Huixiong Xu, Wenwen Yue
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Advanced Science
Subjects:
checkpoint blockade
immunotherapy
myeloid cells
nanomedicine
tumor therapy
Online Access:https://doi.org/10.1002/advs.202104619

Internet

https://doi.org/10.1002/advs.202104619

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