Honokiol suppresses formyl peptide-induced human neutrophil activation by blocking formyl peptide receptor 1

Honokiol suppresses formyl peptide-induced human neutrophil activation by blocking formyl peptide receptor 1

Abstract Formyl peptide receptor 1 (FPR1) mediates bacterial and mitochondrial N-formyl peptides-induced neutrophil activation. Therefore, FPR1 is an important therapeutic target for drugs to treat septic or sterile inflammatory diseases. Honokiol, a major bioactive compound of Magnoliaceae plants,...

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Bibliographic Details
Main Authors: Fu-Chao Liu, Huang-Ping Yu, Yu-Ting Syu, Jia-You Fang, Chwan-Fwu Lin, Shih-Hsin Chang, Yen-Tung Lee, Tsong-Long Hwang
Format: Article
Language:English
Published: Nature Portfolio 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07131-w

Internet

https://doi.org/10.1038/s41598-017-07131-w

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