Retinal imaging demonstrates reduced capillary density in clinically unimpaired APOE ε4 gene carriers

Retinal imaging demonstrates reduced capillary density in clinically unimpaired APOE ε4 gene carriers

Abstract Introduction Apolipoprotein E (APOE) ε4, the strongest non‐Mendelian genetic risk factor for Alzheimer's disease (AD), has been shown to affect brain capillaries in mice, with potential implications for AD‐related neurodegenerative disease. However, human brain capillaries cannot be di...

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Bibliographic Details
Main Authors: Fanny M. Elahi, Senyo B. Ashimatey, Daniel J. Bennett, Samantha M. Walters, Renaud La Joie, Xuejuan Jiang, Amy Wolf, Yann Cobigo, Adam M. Staffaroni, Howie J. Rosen, Bruce L. Miller, Gil D. Rabinovici, Joel H. Kramer, Ari J. Green, Amir H. Kashani
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Alzheimer's disease
apolipoprotein E ε4
capillary rarefaction
preclinical biomarker
preclinical disease
vascular contributions to Alzheimer's disease
Online Access:https://doi.org/10.1002/dad2.12181

Internet

https://doi.org/10.1002/dad2.12181

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