Development of Sustained Release Baricitinib Loaded Lipid-Polymer Hybrid Nanoparticles with Improved Oral Bioavailability

Development of Sustained Release Baricitinib Loaded Lipid-Polymer Hybrid Nanoparticles with Improved Oral Bioavailability

Baricitinib (BTB) is an orally administered Janus kinase inhibitor, therapeutically used for the treatment of rheumatoid arthritis. Recently it has also been approved for the treatment of COVID-19 infection. In this study, four different BTB-loaded lipids (stearin)-polymer (Poly(<span style="...

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Bibliographic Details
Main Authors: Md. Khalid Anwer, Essam A. Ali, Muzaffar Iqbal, Mohammed Muqtader Ahmed, Mohammed F. Aldawsari, Ahmed Al Saqr, Mohd Nazam Ansari, M. Ali Aboudzadeh
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
baricitinib
bioavailability
encapsulation
hybrid nanoparticles
poly(<span style="font-variant: small-caps">d</span>,<span style="font-variant: small-caps">l</span>-lactide-coglycolide)
stearin
Online Access:https://www.mdpi.com/1420-3049/27/1/168

Internet

https://www.mdpi.com/1420-3049/27/1/168

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