In vitro phenotypic, genomic and proteomic characterization of a cytokine-resistant murine β-TC3 cell line.

In vitro phenotypic, genomic and proteomic characterization of a cytokine-resistant murine β-TC3 cell line.

Type 1 diabetes mellitus (T1DM) is caused by the selective destruction of insulin-producing β-cells. This process is mediated by cells of the immune system through release of nitric oxide, free radicals and pro-inflammatory cytokines, which induce a complex network of intracellular signalling cascad...

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Main Authors: Antonina Coppola, Laura Tomasello, Giuseppe Pizzolanti, Ida Pucci-Minafra, Nadia Albanese, Gianluca Di Cara, Patrizia Cancemi, Maria Pitrone, Alessandra Bommarito, Elvira Carissimi, Giovanni Zito, Angela Criscimanna, Aldo Galluzzo, Carla Giordano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3290556?pdf=render

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http://europepmc.org/articles/PMC3290556?pdf=render

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