Immobilized collagen prevents shedding and induces sustained GPVI clustering and signaling in platelets

Immobilized collagen prevents shedding and induces sustained GPVI clustering and signaling in platelets

Collagen, the most thrombogenic constituent of blood vessel walls, activates platelets through glycoprotein VI (GPVI). In suspension, following platelet activation by collagen, GPVI is cleaved by A Disintegrin And Metalloproteinase (ADAM)10 and ADAM17. In this study, we use single-molecule localizat...

Full description

Bibliographic Details
Main Authors: Chiara Pallini, Jeremy A. Pike, Christopher O’Shea, Robert K. Andrews, Elizabeth E. Gardiner, Steve P. Watson, Natalie S. Poulter
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Platelets
Subjects:
glycoprotein (gp) vi
platelets
receptor shedding
signaling
super resolution microscopy
Online Access:http://dx.doi.org/10.1080/09537104.2020.1849607

Internet

http://dx.doi.org/10.1080/09537104.2020.1849607

Similar Items