Cyclic-di-AMP Phosphodiesterase Elicits Protective Immune Responses Against Mycobacterium tuberculosis H37Ra Infection in Mice

Cyclic-di-AMP Phosphodiesterase Elicits Protective Immune Responses Against Mycobacterium tuberculosis H37Ra Infection in Mice

Many antigens from Mycobacterium tuberculosis (M. tuberculosis) have been demonstrated as strong immunogens and proved to have application potential as vaccine candidate antigens. Cyclic di-AMP (c-di-AMP) as a bacterial second messenger regulates various bacterial processes as well as the host immun...

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Bibliographic Details
Main Authors: Yanzhi Lu, Huanhuan Ning, Jian Kang, Guangchun Bai, Lei Zhou, Yali Kang, Zhengfeng Wu, Maolin Tian, Junhao Zhao, Yueyun Ma, Yinlan Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacterium tuberculosis
cyclic-di-AMP
phosphodiesterase
immune response
infection
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.871135/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.871135/full

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