When Helpers Go Above and Beyond: Development and Characterization of Cytotoxic CD4+ T Cells

Once regarded as an experimental artefact, cytotoxic CD4+ T cells (CD4 CTL) are presently recognized as a biologically relevant T cell subset with important functions in anti-viral, anti-tumor, and autoimmune responses. Despite the potentially large impact on their micro-environment, the absolute ce...

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Bibliographic Details
Main Authors: Cindy Hoeks, Gayel Duran, Niels Hellings, Bieke Broux
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.951900/full