Global gene expression and systems biology analysis of bovine monocyte-derived macrophages in response to in vitro challenge with Mycobacterium bovis.

BACKGROUND: Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cell types to encounter M. bovis following exposure and the response elicited by these cells is pivotal in determining the outcome...

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Main Authors: David A Magee, Maria Taraktsoglou, Kate E Killick, Nicolas C Nalpas, John A Browne, Stephen D E Park, Kevin M Conlon, David J Lynn, Karsten Hokamp, Stephen V Gordon, Eamonn Gormley, David E MacHugh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3284544?pdf=render