Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability.
Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a sequence and acetylation dependent way regulating the...
| Main Authors: | , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Public Library of Science (PLoS)
2016-01-01
|
| Colecção: | PLoS ONE |
| Acesso em linha: | http://europepmc.org/articles/PMC4942050?pdf=render |