Modulation of Connexin-36 Gap Junction Channels by Intracellular pH and Magnesium Ions

Modulation of Connexin-36 Gap Junction Channels by Intracellular pH and Magnesium Ions

Connexin-36 (Cx36) protein forms gap junction (GJ) channels in pancreatic beta cells and is also the main Cx isoform forming electrical synapses in the adult mammalian brain. Cx36 GJs can be regulated by intracellular pH (pHi) and cytosolic magnesium ion concentration ([Mg2+]i), which can vary signi...

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Bibliographic Details
Main Authors: Lina Rimkute, Tadas Kraujalis, Mindaugas Snipas, Nicolas Palacios-Prado, Vaidas Jotautis, Vytenis A. Skeberdis, Feliksas F. Bukauskas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Physiology
Subjects:
connexin-36
gap junctions
intracellular pH and Mg2+
mutants
cell culture
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00362/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2018.00362/full

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