Increased AR expression in castration-resistant prostate cancer rapidly induces AR signaling reprogramming with the collaboration of EZH2

Increased AR expression in castration-resistant prostate cancer rapidly induces AR signaling reprogramming with the collaboration of EZH2

Elevated androgen receptor (AR) expression is a hallmark of castration-resistant prostate cancer (CRPC) and contributes to the restoration of AR signaling under the conditions of androgen deprivation. However, whether overexpressed AR alone with the stimulation of castrate levels of androgens can be...

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Detalles Bibliográficos
Main Authors: Maryam Labaf, Muqing Li, Lily Ting, Breelyn Karno, Songqi Zhang, Shuai Gao, Susan Patalano, Jill A. Macoska, Kourosh Zarringhalam, Dong Han, Changmeng Cai
Formato: Artigo
Idioma:English
Publicado: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
androgen
androgen receptor
AR
prostate cancer
androgen-deprivation therapy
CRPC
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fonc.2022.1021845/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1021845/full

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