Mapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway

Mapping the SLP76 interactome in T cells lacking each of the GRB2-family adaptors reveals molecular plasticity of the TCR signaling pathway

The propagation and diversification of signals downstream of the T cell receptor (TCR) involve several adaptor proteins that control the assembly of multimolecular signaling complexes (signalosomes). The global characterization of changes in protein-protein interactions (PPI) following genetic pertu...

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Bibliographic Details
Main Authors: Kilian Ruminski, Javier Celis-Gutierrez, Nicolas Jarmuzynski, Emilie Maturin, Stephane Audebert, Marie Malissen, Luc Camoin, Guillaume Voisinne, Bernard Malissen, Romain Roncagalli
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
TCR
SLP76
GRB2-family adaptors
mass spectrometry
T cell signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139123/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139123/full

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