Case report: Supratherapeutic tacrolimus concentrations with nirmatrelvir/ritonavir in a lung transplant patient: a case report using Rifampin for reversal

Case report: Supratherapeutic tacrolimus concentrations with nirmatrelvir/ritonavir in a lung transplant patient: a case report using Rifampin for reversal

Paxlovid (nirmatrelvir/ritonavir) is an antiviral drug used to treat COVID-19, nirmatrelvir, a SARS-CoV-2 main protease inhibitor, works by inhibiting viral replication in the early stages, and ritonavir is a strong cytochrome P450 (CYP) 3A inhibitor that helps the nirmatrelvir reach and maintain th...

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Bibliographic Details
Main Authors: Yu Xiong, Xiaoxing Wang, Shu Li, Qian Zhang, Lijuan Guo, Wenhui Chen, Zhixia Zhao, Lihong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
PAXLOVID
nirmatrelvir/ritonavir
tacrolimus toxicity
drug-drug interactions
Rifampin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1285078/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1285078/full

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