Lead suppresses interferon γ to induce splenomegaly via modification on splenic endothelial cells and lymphoid tissue organizer cells in mice

Lead suppresses interferon γ to induce splenomegaly via modification on splenic endothelial cells and lymphoid tissue organizer cells in mice

Splenomegaly is a symptom characterized by the presence of an enlarged spleen. The impact of environmental factors on splenomegaly is largely unknown. In this study, C57BL/6 mice were treated with 125 ppm or 1250 ppm lead (Pb) via drinking water for 8 wk, and the process of splenomegaly was evaluate...

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Bibliographic Details
Main Authors: Yue Zhai, Yifan Zhao, Yufan Zhang, Jinyi He, Mengke Tang, Yalin Liu, Guangrui Yang, Peng Xue, Ye Yao, Miao He, Yanyi Xu, Weidong Qu, Yubin Zhang
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Lead
Splenomegaly
Endothelial cells
Lymphoid tissue organizer cells
Interferon γ/Jak1/STAT1
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322008867

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http://www.sciencedirect.com/science/article/pii/S0147651322008867

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