Lipid environment determines the drug-stimulated ATPase activity of P-glycoprotein

Lipid environment determines the drug-stimulated ATPase activity of P-glycoprotein

P-glycoprotein (Pgp) is a multidrug transporter that uses the energy from ATP binding and hydrolysis to export from cells a wide variety of hydrophobic compounds including anticancer drugs, and mediates the bioavailability and pharmacokinetics of many drugs. Lipids and cholesterol have been shown to...

Full description

Bibliographic Details
Main Authors: Nghi N. B. Tran, A. T. A. Bui, Valeria Jaramillo-Martinez, Joachim Weber, Qinghai Zhang, Ina L. Urbatsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
P-glycoprotein
multidrug ABC transporter
verapamil-stimulated ATPase activity
membrane lipid composition
artificial plasma membrane mimic
mixed detergent/lipid micelles
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1141081/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1141081/full

Similar Items