Study on endocrine disruption effect of paclobutrazol and uniconazole on the thyroid of male and female rats based on lipidomics

The present study investigated the effects of paclobutrazol and uniconazole on thyroid endocrine system in rats. Lipidomic analysis was performed to obtain the biomarkers of thyroid endocrine disruption induced by paclobutrazol and uniconazole. Network pharmacology was further used to discover poten...

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Bibliographic Details
Main Authors: Hui Liu, Yanyan Xu, Yuming Wang, Chunyang Liu, Jun Chen, Simiao Fan, Lijuan Xie, Yaqian Dong, Siyu Chen, Wenjie Zhou, Yubo Li
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322002263