Structural basis for lipid and copper regulation of the ABC transporter MsbA

Structural basis for lipid and copper regulation of the ABC transporter MsbA

The bacterial ABC transporter MsbA is essential for lipopolysaccharide biogenesis. Here, the authors apply native mass spectrometry, X-ray crystallography, cryo-EM and biochemical approaches to characterize the structural basis and functional roles of MsbA binding to copper and specific lipids.

Bibliographic Details
Main Authors: Jixing Lyu, Chang Liu, Tianqi Zhang, Samantha Schrecke, Nicklaus P. Elam, Charles Packianathan, Georg K. A. Hochberg, David Russell, Minglei Zhao, Arthur Laganowsky
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34905-2

Internet

https://doi.org/10.1038/s41467-022-34905-2

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