Perspectives of differentiation therapies of acute myeloid leukemia: the search for the molecular basis of patients’ variable responses to 1,25-dihydroxyvitamin D and vitamin D analogs.

Perspectives of differentiation therapies of acute myeloid leukemia: the search for the molecular basis of patients’ variable responses to 1,25-dihydroxyvitamin D and vitamin D analogs.

The concept of differentiation therapy of cancer is approximately 40 years old. Despite many encouraging results obtained in laboratories, both in vitro and in vivo studies, the only really successful clinical application of differentiation therapy was all-trans-retinoic acid (ATRA) based therapy of...

Full description

Bibliographic Details
Main Authors: Aleksandra eMarchwicka, Małgorzata eCebrat, Preetha eSampath, Łukasz eŚnieżewski, Ewa Teresa Marcinkowska
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Oncology
Subjects:
Vitamin D
gene
differentiation
acute myeloid leukemia (AML)
retinoic acid receptor alpha
vitamin D receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00125/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00125/full

Similar Items