regSNPs-ASB: A Computational Framework for Identifying Allele-Specific Transcription Factor Binding From ATAC-seq Data

regSNPs-ASB: A Computational Framework for Identifying Allele-Specific Transcription Factor Binding From ATAC-seq Data

Expression quantitative trait loci (eQTL) analysis is useful for identifying genetic variants correlated with gene expression, however, it cannot distinguish between causal and nearby non-functional variants. Because the majority of disease-associated SNPs are located in regulatory regions, they can...

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Bibliographic Details
Main Authors: Siwen Xu, Weixing Feng, Zixiao Lu, Christina Y. Yu, Wei Shao, Harikrishna Nakshatri, Jill L. Reiter, Hongyu Gao, Xiaona Chu, Yue Wang, Yunlong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
expression quantitative trait loci
allele-specific binding
transcription factor
ATAC-seq
functional single-nucleotide polymorphisms
computational biology
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00886/full

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https://www.frontiersin.org/article/10.3389/fbioe.2020.00886/full

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