Epigenetic Regulation of Inflammatory Cytokine-Induced Epithelial-To-Mesenchymal Cell Transition and Cancer Stem Cell Generation

Epigenetic Regulation of Inflammatory Cytokine-Induced Epithelial-To-Mesenchymal Cell Transition and Cancer Stem Cell Generation

The neoplastic transformation of normal to metastatic cancer cells is a complex multistep process involving the progressive accumulation of interacting genetic and epigenetic changes that alter gene function and affect cell physiology and homeostasis. Epigenetic changes including DNA methylation, hi...

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Bibliographic Details
Main Authors: Georgios S. Markopoulos, Eugenia Roupakia, Kenneth B. Marcu, Evangelos Kolettas
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
inflammatory cytokines
epithelial-to-mesenchymal cell transition (emt)
inflammatory cytokine-induced emt (ici-emt)
cancer stem cells (cscs)
tumor microenvironment (tme)
transcription factors (tfs)
epigenetic regulators
feedback regulatory loops
Online Access:https://www.mdpi.com/2073-4409/8/10/1143

Internet

https://www.mdpi.com/2073-4409/8/10/1143

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