SARS-CoV-2 Inhibits NRF2-Mediated Antioxidant Responses in Airway Epithelial Cells and in the Lung of a Murine Model of Infection

SARS-CoV-2 Inhibits NRF2-Mediated Antioxidant Responses in Airway Epithelial Cells and in the Lung of a Murine Model of Infection

ABSTRACT Several viruses have been shown to modulate the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2), the master regulator of redox homeostasis. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for the COVID-19 pandemic, also seems to disrupt...

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Bibliographic Details
Main Authors: Yue Qu, Aline Haas de Mello, Dorothea R. Morris, Yava L. Jones-Hall, Teodora Ivanciuc, Rachel A. Sattler, Slobodan Paessler, Vineet D. Menachery, Roberto P. Garofalo, Antonella Casola
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
COVID-19
NRF2
antioxidant enzymes
Nrf2-deficient mice
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00378-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00378-23

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